Authors Mhurchu CN.
Dunshea-Mooij C. Bennett D. Rodgers A.
Institution Clinical Trials Research
Unit, University of Auckland, Auckland, New Zealand.
Title Effect of chitosan on weight
loss in overweight and obese individuals: a systematic review of
randomized controlled trials.
Source Obesity Reviews. 6(1):35-42, 2005
Abstract This article aims to
determine whether chitosan, a popular, over-the-counter, weight loss
supplement, is an effective treatment for overweight and obesity. It is
designed as a systematic review of randomized controlled trials. The data
sources include the electronic databases Medline, EMBASE, Biosis, CINAHL
and Cochrane Central Register of Controlled Trials (CCTR); the specialized
websites Controlled Trials, International Bibliographic Information on
Dietary Supplements (IBIDS), System for Information on Grey Literature in
Europe (SIGLE), Reuter's Health Service, Natural Alternatives
International and Pharmanutrients; and bibliographies of relevant journal
articles. Included were randomized controlled trials of chitosan with a
minimum duration of 4 weeks in adults who were overweight or obese and/or
had hypercholesterolaemia at baseline. Fourteen trials involving a total
of 1071 participants were included in the review. Analyses involving all
trials indicated that chitosan preparations
result in a small but statistically significant greater reduction in body
weight (weighted mean difference -1.7 kg; 95% confidence interval -2.1,
-1.3 kg, P < 0.00001) compared with placebo. Analyses
restricted to high-quality studies showed that reductions in weight [-0.6
(-1.2, 0.1) kg, P = 0.11] were less than in lower quality studies [-2.3
(-2.7, -1.8) kg, P < 0.00001]. Results obtained
from high-quality trials indicate that the effect of chitosan on body
weight is minimal and unlikely to be of clinical significance.