Chinese Medical Information Portal Website (Taiwan Medical Network-TMN) - OldDoc Wu's Series
(Established in March 1996)
Dr. Wu's Liver diseases
for professionals (medical students and residents)
(Posted Sep. 16, 1996; Updated May 14, 2009)
Viral hepatitis F and G
(Key words: HFV, HGV, hepatitis G virus, hepatitis F, hepatitis G)
Viral hepatitis F (a variant of HBV ?):
- After the discovery of hepatitis virus A, B, C, D, and E, a few
viral hepatitis cases, both post-transfusion and sporadic, which
are failed to be ascribed to A ~ E, were observed.
- In 1991 ~ 1992, investigators in Japan reported the discovery
of a new hepatitis virus and called it as hepatitis virus F, but
failed to be substantiated in the subsequent research.
- In 1993, Uchida of Japan reported by PCR study that the so-called
hepatitis virus F might be a mutant of HBV, just could not be
verified by commercially available reagents because of the defect
pre-C gene, mutation of core gene and S gene, which come to be
HBsAg (-) and anti-HBc (-) in serological tests. (Uchida T: Microbiol
Immunol 37: 425 ~ 439, 1993; J Hepatol 18: 369 ~ 372, 1993)
- In 1994, Deka reported an isolation of a virus named HFV (Hepatitis French[origin] Virus) on intravenous innoculation of stool extract from sporadic non-A, non-B hepatitis, in New Delhi, India,however, no follow-up report was noted. (Deka N; et al.:J. Virol; 68:7810~5, 1994)
Viral hepatitis G: (HGBV-C/HGV)
- Non-A ~ E viral hepatitis.
- 1995: Simons (Abbott) identified new novel virus termed GBV-C.
- 1996: Linnen (Genelab) identified another novel virus termed HGV.
- 1996: GBV-C and HGV are identified to have the same/or very similar
structure and contain two flavivirus sequences related to, but
far distinct from the HCV.
- Suggested better termed HGBV-C/HGV for the time being.
- It is still contoversial if HGV will be the cause of acute, fulminant, and chronic hepatitis.
- HGBV-C/HGV has also been identified in Taiwan.
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(By Jau-Shin Wu, M.D.; Posted Sep. 16, 1996; Revised May 12, 2009)
(TMN) Since June 09, 2002
(Dr. Wu's Liver D) Since Jan. 01, 2008
(Olddoc)Since Jan. 01, 2008
(TMN) Since Jan. 01, 2008