Chinese Medical Information Portal Website (Taiwan Medical Network-TMN) - OldDoc Wu's Series
(Established in March 1996)
Viral hepatitis D
Dr. Wu's Liver diseases
for professionals (medical students and residents)

(by Jau-Shin WU, M.D., Ph.D.)
(Posted Sep. 16, 1996; Updated May 14, 2009)


Viral hepatitis D

For consumers:

(Key words: HDV, hepatitis D virus, hepatitis D)

For professionals:

  • RNA virus, 35 ~ 37 nm.

  • Defective virus, a virus-like particle consisting of a coat of HBsAg and a unique internal antigen, the delta antigen.

  • Require coinfection with HBV for viral replication.

  • Discovered in 1977 by Rizetto, in nuclei of hepatocytes from patients with chronic HBV infection, and originally was thought to be HBcAg.

  • Infection: 1) co-infection 2) superinfection

  • Coinfection: concurrent infection of HBV and HDV at the same time.

  • Superinfection: HDV infection occurs in persons with chronic HBV infection.

  • Concurrent infection in Taiwan:

    • anti-HDV (+):

      • in 3% of asymptomatic HBV carriers.

      • in 20% of chronic active hepatitis B.

      • in 50% of HBsAg (+) female prostitutes.

      • In 88% of HBsAg (+) IVDUs.

  • The most fulminant cases occur in superinfections rather than co-infections.

    [Dr. Wu's Health Note- Home] [Taiwan Medical Network]
    [Web sites for medical students][Curriculum Vitae ]

    (By Jau-Shin Wu, M.D.; Posted Sep. 16, 1996; Revised May 12, 2009)

    (TMN) Since June 09, 2002

    (Dr. Wu's Liver D) Since Jan. 01, 2008

    (Olddoc)Since Jan. 01, 2008

    (TMN) Since Jan. 01, 2008