Chinese Medical Information Portal Website (Taiwan Medical Network-TMN) - OldDoc Wu's Series
(Established in March 1996)
Dr. Wu's Liver diseases
for professionals (medical students and residents)
(Posted Sep. 16, 1996; Updated May 14, 2009)
Transmission of HCV
(Key words: HCV, transmission)
- Transfusion of infected blood or blood products or transplantation of infected organs, and sharing of contaminated needles are the most common causes of HCV infection.
TRANSMISSION OF HEPATITIS C VIRUS-------- ROUTE, DOSE, AND TITER
- 1. HCV -- low titer of virus in the blood of patients.
- 2. Most efficient transmission of HCV --------
the transfusion of infected blood or blood products or transplantation of infected organs, and sharing of contaminated needles.
- 3. < 50% of acute C hepatitis --- with history of exposure
- 4. Small number of studies --- demonstrate perinatal, sexual, household, and occupational
- 5. Mother to infant transmission:
- 6% (3/53) of anti-HCV positive mother
- 11% of HCV-RNA positive mother
- 36% of HCV-RNA positive mother with titers of at least 10/ml, 0% with titer below 10/ml.
- Transmission directly related to the level of viremia in the mother.
- Nucleotide sequencing of the HCV genomes from the infected infants and their mothers --- nearly identical,
(97 to 99 %).
- 6. Serological studies of sexual partners (0~30%), and houshold contacts of children (0~20%)
- 7. Type and size of inoculum and the route of transmission, as well as the titer of virus related to the risk of transmission.
(From: Alter, M.J., N.Eng.J.M. 330:764, 1994)
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(By Jau-Shin Wu, M.D.; Posted Sep. 16, 1996; Revised May 12, 2009)
(TMN) Since June 09, 2002
(Dr. Wu's Liver D) Since Jan. 01, 2008
(Olddoc)Since Jan. 01, 2008
(TMN) Since Jan. 01, 2008