Chinese Medical Information Portal Website (Taiwan Medical Network-TMN) - OldDoc Wu's Series
(Established in March 1996)
Chronic Hepatitis (History)
Dr. Wu's Liver diseases
for professionals (medical students and residents)

(by Jau-Shin WU, M.D., Ph.D.)
(Posted Sep. 16, 1996; Updated May 14, 2009)


Chronic Hepatitis (History)

For consumers:

(Key words: chronic hepatitis, history, syndrome)

For professionals:


  1. Original classification---1968 (De Grote:A classification of chronic hepatitis, Lancet 2:626)

    • ----- at that time, most cases: causes unknown (autoimmune)

    • ----- the proposed classification was aimed at distinguishing subgroups according to the degree of disease activity to provide prognostic information and criteria for the use of immunosuppressive therapy (prognosis, immunotherapy)

      • a) chronic persistent hepatitis---milder activity

      • b) chronic aggressive(active) hepatitis---more severe activity

    • Histological basis:

      • initially --- emphasis on the presence of periportal piecemeal necrosis

      • later ---identify the importance of lobular parenchymal lesions esp. bridging hepatic necrosis which tends to progress to cirrhosis

  2. Revised classification:(1994)

    • International Working Party, Working Congress of Gastroenterology
      • -----Diagnosis is primarily based on etiology

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(By Jau-Shin Wu, M.D.; Posted Sep. 16, 1996; Revised May 12, 2009)

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